SEATTLE (AP) — Amanda Knox is back on American soil after four years in an Italian prison.

A British Airways plane carrying Knox and her parents from London landed Tuesday evening at Seattle-Tacoma International Airport.

The 24-year-old Seattle native was freed after an Italian appeals court on Monday threw out her conviction in the sexual assault and fatal stabbing of her British roommate. The University of Washington student was studying abroad in Perugia.

The conviction was overturned amid doubts over DNA evidence. Prosecutors insist she was among three people who killed 21-year-old Meredith Kercher.

Knox has become a tabloid staple on two continents.

A family spokesman says Knox’s parents and her legal adviser are expected to speak to reporters.

The acquittal of the American and her ex-boyfriend in the murder of her British roommate left open the core mystery of whether anyone — other than the lone man still behind bars — took part in the brutal killing.

But it also begged questions that stretch back to the early days of the investigation into the 2007 death of Meredith Kercher.

A third defendant, Rudy Hermann Guede of the Ivory Coast, was convicted in a separate trial of sexually assaulting and stabbing Kercher, and his 16-year prison sentence — reduced on appeal from an initial 30 years — was upheld by Italy’s highest court in 2010.