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Cayman Chemical Co promotes Zileuton

Cayman ChemicalsZileuton – Cayman Chemical Item Number 10006967

There is substantial evidence that the cysteinyl-leukotrienes (cysLTs), such as LTC4, LTD4, and LTE4, play an important role in the pathophysiology of asthma.1,2 Arachidonic acid is the precursor fatty acid that is transformed into LTs by way of the 5-lipoxygenase (5-LO) pathway. Zileuton (Zyflo™) is a reversible 5-LO inhibitor that was approved in 1997 for the prevention and treatment of asthma in the USA, but was withdrawn by Abbott Laboratories in 2003.3,4 Zileuton inhibits 5-LO from rat basophilic leukemia-1 (RBL-1) cells with an IC50 value of 0.5 µM. It is a potent inhibitor of leukotriene B4 production in purified human peripheral blood polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.6 µM.3

 

10006967Synonyms                  Zyflo™

Formal Name             N-​(1-​benzo[b]thien-​2-​ylethyl)-​N-​hydroxy-​urea

CAS Number              111406-87-2

Molecular Formula    C11H12N2O2S

Formula Weight        236.3

Formulation               A crystalline solid

Purity                            >98%

Stability                      2 years

Storage                       -20°C

Shipping                     Room temperature in continental US; may vary elsewhere

SMILES                       CC(N(C(N)​=O)​O)​C(S1)​=CC2=C1C=CC=C2

5 mg                           $16.00

10 mg                                     $30.00

25 mg                                     $72.00

50 mg                                     $128.0

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

For more on this story go to:

https://www.caymanchem.com/app/template/Product.vm/catalog/10006967

 

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