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Dr. Stuart Weiss: COVID-19 Update Monday 9-September-2020

Dr. Stuart Weiss, FACEP, FAAP, CBCP

September 8, 2020

AstraZeneca Halts vaccine trial

Reported in the New York Times and STAT News

Astrazeneca, one of three companies in the US in late stage phase three trials has paused its global trials of its AZD1222 CoViD-19 vaccine because of a serious and unexpected adverse reaction in a British volunteer.

The vaccine trial’s halt will allow the company to conduct a safety review of a condition called transverse myelitis which is an inflammatory condition affecting the spinal cord. In large scale trials, these unusual reactions sometimes occur and must be investigated. This is the reason that phase three large scale trials are important. It helps to bring out rare and unusual effects of a vaccine. It is also possible that this person developed this condition independent of the trial so this must be fully investigated. 

The Astrazeneca vaccine relies on a chimpanzee adenovirus that has been modified to carry SARS-CoV-2 genes into human cells. The chimp adenovirus is thought to be harmless in humans and the coronavirus components are thought to incite an immune response should a person come into contact with actual coronavirus in the future. However, sometimes Adenoviruses incite their own immune responses which can harm patients and this must be investigated. 

The company is working to investigate this and hopes to avoid any impact on the trial timeline.

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COVID-19 HEADLINES 
Coronavirus update for September 8, 2020

World Wide Updates

AstraZeneca Pauses Vaccine Trial for Safety Review
Some World Cup qualifying games moved to 2021 because of the pandemic
Hong Kong to relax social distancing measures from Friday
South Africa’s economy contracts 17% in Q2, as coronavirus hits
Nine vaccine makers sign safety pledge in race for Covid-19 vaccine
As UK coronavirus cases rise, “people have relaxed too much” officials warn
Pfizer-BioNTech vaccine could be ready for approval by mid-October — but there are still “unknowns”
Spain heads back to school, but the pandemic is exposing inequality
Hong Kong in travel bubble talks with 11 countries across Europe and Asia
Trickle of passengers as Delhi subway returns from coronavirus lockdown
Mexico reports nearly 3,500 new Covid-19 cases
New graphics from WHO illustrate dire pandemic conditions in Americas compared to rest of world
Xi Jinping says China acted in a “transparent, and responsible manner” on Covid-19
France records more than 6,000 new cases
Spain reports more than 3,00 cases in the past 24 hours
Three migrant camps near Athens placed in quarantine as concerns mount over spread
Tour de France director tests positive for COVID-19
India sees highest deaths in a month, lowest cases in a week
China’s leaders staged a triumphant ceremony to celebrate beating the coronavirus on Tuesday
Jordan has resumed regular international flights after being suspended for nearly six months due to pandemic, officials said
EasyJet cutting flights following the government’s decision to impose quarantine restrictions for seven Greek islands
Canada seeing an increase in people infected as schools across the country begin to reopen
World Tennis women’s number one Ashleigh Barty of Australia announces she will not defend her French Open crown due to coronavirus fears
The European Parliament cancels plans to hold a plenary session in Strasbourg next week
India’s Taj Mahal is set to reopen on September 21
Total Cases Worldwide: 27,668,373
Total Deaths Worldwide: 899,610
Total Recovered: 19,732,911

US Updates

More than half a million US children have been diagnosed with Covid-19
New York continues to have an infection rate under 1%, governor says
Fauci says vaccine unlikely to be ready by Election Day
House Democrat and consumer advocacy group call on Trump to let generic drug makers produce remdesivir
Pelosi says GOP stimulus plan “insults the intelligence of the American people”
Connecticut governor says his state struggled to obtain supplies during the early days of the pandemic
96% of NYC public school classrooms have passed ventilation inspection, mayor says
Senate will vote Thursday on advancing GOP stimulus bill
More than 37,000 Covid-19 cases have been reported at colleges and universities in all 50 states
Vermont governor says testing and contact tracing will be key to keeping schools open
People obeying stay-at-home orders in the spring was associated with drop in Covid-19 spread, study suggests
Tuscaloosa mayor reopens bars despite University of Alabama case spike
Inovio plans to start Phase 2/3 clinical trials of Covid-19 vaccine this month
Hartford cyberattack that delayed back-to-school is one of the most significant in last 5 years, mayor says
Pennsylvania restaurants can move to 50% indoor capacity later this month, governor says
Texas governor extends Covid-19 disaster declaration
First day of school postponed in Hartford, Connecticut, after ransomware virus
TSA screened 36% of last year’s traffic over Labor Day weekend
Trump’s net worth dips by 19.4% as coronavirus pandemic dings real estate
Washington State women’s basketball coach busted for block party despite coronavirus shutdown
Giant frat party at University of New Hampshire sparks coronavirus cluster
University of Tennessee is having a “significant issue” with Covid-19 stemming from fraternities
New York puts Ohio back on travel advisory list
Doctors studying why obesity may be tied to serious COVID-19
Computer glitches disrupt classes as schools return online
Total US cases: 6,503,671Total US deaths: 193,856Total Recovered: 3,779,728Total Tested in US: 83,450,642
Total cases in CA: 742,827
Total deaths in CA: 13,787
Total cases in TX: 668,787
Total deaths in TX: 13,819
Total cases in FL: 650,092
Total deaths in FL: 11,919
Total cases in NY: 472,980
Total deaths in NY: 33,100

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